On September 29, 1982, the first of seven reported victims in the Chicago area died after consuming Extra-Strength Tylenol capsules that had been deliberately contaminated with potassium cyanide. Over the next week additional deaths and dozens of reported injuries were linked to the same brand and formulation. The incidents rapidly escalated from a local medical mystery into a national public-health emergency. Johnson & Johnson, the maker of Tylenol, and local authorities moved quickly as evidence accumulated that the poisonings were not accidental. Within days, the company issued warnings, halted production of the product, and—importantly—cooperated with an unprecedented voluntary recall of roughly 31 million bottles of Tylenol nationwide. Retailers pulled products from shelves, and consumers were urged not to use Tylenol capsules pending investigation. The case attracted intense media attention and created widespread fear about the safety of over-the-counter medications. Pharmacies and supermarkets saw empty shelves and altered purchasing patterns as consumers avoided not only Tylenol but similar products sold in capsule form. Law enforcement agencies, including the FBI, launched a high-profile investigation that spanned multiple states and examined possible tampering at manufacturing sites, distribution channels, and retail locations. Despite many leads and extensive investigative work, the person or persons responsible for the poisonings were never conclusively identified or prosecuted. Public-health officials and industry leaders responded by rethinking how nonprescription medicines were packaged and sold. One of the most significant outcomes was the rapid adoption of tamper-resistant packaging across the pharmaceutical and consumer goods industries. Manufacturers introduced triple-seal packaging—inner foil seals, plastic seals, and tamper-evident outer boxes—and the U.S. Food and Drug Administration later issued guidelines and regulations to make over-the-counter medications more tamper-resistant. These changes aimed to restore consumer confidence and to make similar acts of product tampering easier to detect. The Tylenol poisonings also prompted changes in crisis communication practices. Johnson & Johnson’s prompt public warnings, cooperation with authorities, and visible recall efforts have been widely studied by public-relations experts as an example of decisive corporate response in a public-health crisis. At the same time, the events revealed vulnerabilities in product-safety oversight and supply-chain security that prompted ongoing regulatory and industry attention. For the Chicago-area victims and their families, the case left lasting trauma and unanswered questions. The unsolved nature of the attacks spurred various theories and periodic renewed investigations, but no definitive perpetrator emerged in the public record. The incident remains a key reference point in discussions of consumer safety, corporate crisis management, and law enforcement responses to product tampering. More than four decades later, the 1982 Tylenol poisonings are remembered both for their tragic human toll and for the tangible safety reforms they catalyzed. The combination of widespread public alarm, a major corporate recall, and lasting changes to packaging and regulation mark the case as a pivotal moment in modern consumer-protection history.